Recombinant
RabMAb

Anti-Activin Receptor Type IA antibody [EPR4076(2)] (ab155981)

Overview

  • Product name
    Anti-Activin Receptor Type IA antibody [EPR4076(2)]
    See all Activin Receptor Type IA primary antibodies
  • Description
    Rabbit monoclonal [EPR4076(2)] to Activin Receptor Type IA
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to amino acids within Human Activin Receptor Type IA (UniProt ID: Q04771)

  • Positive control
    • Fetal brain, fetal heart and fetal muscle lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab155981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for ICC or IHC-P.
  • Target

    • Function
      On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
    • Tissue specificity
      Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
    • Involvement in disease
      Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
    • Sequence similarities
      Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activin A receptor type I antibody
      • Activin A receptor type II like kinase 2 antibody
      • Activin receptor type I antibody
      • Activin receptor type-1 antibody
      • Activin receptor-like kinase 2 antibody
      • ACTR-I antibody
      • ACTRI antibody
      • Acvr1 antibody
      • ACVR1_HUMAN antibody
      • ACVR1A antibody
      • ACVRLK2 antibody
      • ALK 2 antibody
      • ALK-2 antibody
      • ALK2 antibody
      • FOP antibody
      • Hydroxyalkyl protein kinase antibody
      • Serine/threonine-protein kinase receptor R1 antibody
      • SKR1 antibody
      • TGF-B superfamily receptor type I antibody
      • TGFB superfamily receptor type I antibody
      • TSR-I antibody
      • TSRI antibody
      see all

    Images

    • All lanes : Anti-Activin Receptor Type IA antibody [EPR4076(2)] (ab155981) at 1/1000 dilution

      Lane 1 : Fetal brain lysate
      Lane 2 : Fetal heart lysate
      Lane 3 : Fetal muscle lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labeled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size: 57 kDa
      Observed band size: 57 kDa

    References

    This product has been referenced in:
    • Rigueur D  et al. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res 30:733-41 (2015). Read more (PubMed: 25413979) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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