Anti-Activin Receptor Type IIA antibody [149/1] (ab18103)

Overview

  • Product nameAnti-Activin Receptor Type IIA antibody [149/1]
    See all Activin Receptor Type IIA primary antibodies
  • Description
    Mouse monoclonal [149/1] to Activin Receptor Type IIA
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant intracellular kinase domain of the human type 2 activin A receptor (ACVR2A).

Properties

Applications

Our Abpromise guarantee covers the use of ab18103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 57 kDa.
IP Use at an assay dependent dilution.

Target

  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor type IIA antibody
    • Activin receptor type 2A antibody
    • Activin receptor type IIA antibody
    • Activin receptor type-2A antibody
    • ACTR 2 antibody
    • ACTR IIA antibody
    • ACTR-IIA antibody
    • ACTR2 antibody
    • ACTRII antibody
    • ACTRIIA antibody
    • Acvr 2 antibody
    • Acvr 2A antibody
    • Acvr2 antibody
    • ACVR2A antibody
    • AVR2A_HUMAN antibody
    • OTTHUMP00000197918 antibody
    see all

References for Anti-Activin Receptor Type IIA antibody [149/1] (ab18103)

This product has been referenced in:
  • McCarthy SA  et al. Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2. Hybridoma 13:199-203 (1994). Read more (PubMed: 7927363) »
  • McCarthy SA & Bicknell R Activin-A binds to a heterotrimeric receptor complex on the vascular endothelial cell surface. Evidence for a type 3 activin receptor. J Biol Chem 269:3909-12 (1994). Read more (PubMed: 8307945) »

See all 2 Publications for this product

Product Wall

Application Western blot
Sample Mouse Recombinant protein (HEK293T cells)
Loading amount 5e+006 cells
Specification HEK293T cells
Treatment transfected with cytoplasmic domain of mouse Acvr2b in pDEST26 vector (expected size: 387 amino acids)
Gel Running Conditions Non-reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
Username

Dr. Teresa Gunn

Verified customer

Submitted Aug 08 2007

Thanks for your email and I'm sorry to hear about the bug in your customer's vial. I do apologize, and it is very strange. We will send a vial of ab18103 as a free of charge replacement on your next shipment. Please let me know if you have any ...

Read More

Thank you for your enquiry. The following two references provide more information regarding this antibody: McCarthy SA et al. Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2. Hybridoma 13:199-203 (1994). PubMed: 7927363 Mc...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"