Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16] (ab78412)
Key features and details
- Mouse monoclonal [MM0058-6J16] to Activin Receptor Type IIA/ACVR2A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2
Overview
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Product name
Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16]
See all Activin Receptor Type IIA/ACVR2A primary antibodies -
Description
Mouse monoclonal [MM0058-6J16] to Activin Receptor Type IIA/ACVR2A -
Host species
Mouse -
Specificity
Specific for human Activin RIIA. No cross reactivity was found to hActivin RI and RIIB. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant fragment corresponding to Activin Receptor Type IIA/ACVR2A.
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Positive control
- IHC-P: Human placenta tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
MM0058-6J16 -
Isotype
IgG2 -
Research areas
Associated products
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab78412 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/100.
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Notes |
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IHC-P
1/50 - 1/100. |
Target
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Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 92 Human
- Entrez Gene: 11480 Mouse
- Omim: 102581 Human
- SwissProt: P27037 Human
- SwissProt: P27038 Mouse
- Unigene: 470174 Human
- Unigene: 314338 Mouse
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Alternative names
- Activin A receptor type IIA antibody
- Activin receptor type 2A antibody
- Activin receptor type IIA antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab78412 has been referenced in 1 publication.
- Lin TT et al. Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries. Biol Reprod 98:683-694 (2018). PubMed: 29409020