Overview

  • Product nameAnti-ACVRL1 antibodySee all ACVRL1 primary antibodies ...
  • Description
    Rabbit polyclonal to ACVRL1
  • Tested applicationsELISA, WB, IHC-P more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the sequence of human ACVRL1 within aa 1-100 (N-terminal).

  • Positive control
    • Mouse heart tissue lysate and hepatocarcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab37807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P 1/50 - 1/100.

Target

  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Target information above from: UniProt accession P37023 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor antibody
    • Activin A receptor antibody
    • Activin A receptor type II like 1 antibody
    • Activin A receptor, type II like kinase 1 antibody
    • Activin receptor like kinase 1 antibody
    • Activin receptor-like kinase 1 antibody
    • ACVL1_HUMAN antibody
    • ACVRL1 antibody
    • ACVRLK1 antibody
    • ACVRLK1 antibody
    • ALK-1 antibody
    • ALK1 antibody
    • ALK1 antibody
    • HHT antibody
    • HHT antibody
    • HHT2 antibody
    • HHT2 antibody
    • ORW2 antibody
    • ORW2 antibody
    • Osler Rendu Weber syndrome 2 antibody
    • Serine/threonine protein kinase receptor R3 antibody
    • Serine/threonine-protein kinase receptor R3 antibody
    • SKR3 antibody
    • SKR3 antibody
    • TGF B superfamily receptor type I antibody
    • TGF-B superfamily receptor type I antibody
    • TSR-I antibody
    • TSR1 antibody
    see all

Anti-ACVRL1 antibody images

  • Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate

    Predicted band size : 56 kDa
    Observed band size : 56 kDa
    Additional bands at : 25 kDa,45 kDa,70 kDa. We are unsure as to the identity of these extra bands.
  • ab37807 at a 1/50 dilution detecting ACVRL1 expression in human hepatocarcinoma tissue (a peroxidase-conjugated secondary antibody, followed by AEC staining was used).

    These data demonstrate the suitability of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

References for Anti-ACVRL1 antibody (ab37807)

ab37807 has not yet been referenced specifically in any publications.

Product Wall

Thank you for calling.

As we discussed, I think you should try a different antibody, but no others have been tested for IHC on mouse tissue. I think ab68703 may be a good choice, even though it has not been tested for reactivity with mouse t...

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Thank you for contacting us. While I am unaware of any references describingACVRL1 expression in tumors, the human protein atlas (linked below) does show that "distinct cytoplasmic staining with a granular pattern was observed in thyroid cancers, ...

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