You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-ACVRL1 antibodySee all ACVRL1 primary antibodies ...
  • Description
    Rabbit polyclonal to ACVRL1
  • Tested applicationsELISA, WB, IHC-P more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the sequence of human ACVRL1 within aa 1-100 (N-terminal).

  • Positive controlMouse heart tissue lysate and hepatocarcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab37807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: 1/1000.
WB WB: 1/100 - 1/500. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P IHC-P: 1/50 - 1/100.

Target

  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P37023 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Activin A receptor antibodyActivin A receptor antibodyActivin A receptor type II like 1 antibody
        Activin A receptor, type II like kinase 1 antibodyActivin receptor like kinase 1 antibodyActivin receptor-like kinase 1 antibodyACVL1_HUMAN antibodyACVRL1 antibodyACVRLK1 antibodyACVRLK1 antibodyALK-1 antibodyALK1 antibodyALK1 antibodyHHT antibodyHHT antibodyHHT2 antibodyHHT2 antibodyORW2 antibodyORW2 antibodyOsler Rendu Weber syndrome 2 antibodySerine/threonine protein kinase receptor R3 antibodySerine/threonine-protein kinase receptor R3 antibodySKR3 antibodySKR3 antibodyTGF B superfamily receptor type I antibodyTGF-B superfamily receptor type I antibodyTSR-I antibodyTSR1 antibody
      see all

    Anti-ACVRL1 antibody images

    • Western blot - ACVRL1 antibody (ab37807)
      Western blot - ACVRL1 antibody (ab37807)
      Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate

      Predicted band size : 56 kDa
      Observed band size : 56 kDa
      Additional bands at : 25 kDa,45 kDa,70 kDa. We are unsure as to the identity of these extra bands.
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ACVRL1 antibody (ab37807)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ACVRL1 antibody (ab37807)
      ab37807 at a 1/50 dilution detecting ACVRL1 expression in human hepatocarcinoma tissue (a peroxidase-conjugated secondary antibody, followed by AEC staining was used).

      These data demonstrate the suitability of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

    References for Anti-ACVRL1 antibody (ab37807)

    ab37807 has not yet been referenced specifically in any publications.

    Publishing research using ab37807 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab37807 Submit a Question for ab37807

    Displaying 1 - 2 of 2 results for Abreviews and Q&A

    10
    Votes: Highest First

    I used this product to stain paraffin sections. I tried more than 30 sections in 2 replicates, with or without antigen retrieval by heating, however no a single positive cell was seen, on bone, cartilage or ligament.As far as we know, this receptor is exp...

    Read More

    Thank you for calling.

    As we discussed, I think you should try a different antibody, but no others have been tested for IHC on mouse tissue. I think ab68703 may be a good choice, even though it has not been tested for reactivity with mouse tiss...

    Read More

    I would like to order Anti ACVRL antibody #37807 from abcam for staining tumour samples. Since ALK is a endothelial specific marker...I should see only blood vessels positive, however, in the data sheet of your product you have photographs showing all the...

    Read More

    Thank you for contacting us. While I am unaware of any references describingACVRL1 expression in tumors, the human protein atlas (linked below) does show that "distinct cytoplasmic staining with a granular pattern was observed in thyroid cancers, mal...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"