Overview

  • Product nameAnti-ACVRL1 antibody
    See all ACVRL1 primary antibodies
  • Description
    Rabbit polyclonal to ACVRL1
  • Tested applicationsELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the sequence of human ACVRL1 within aa 1-100 (N-terminal).

  • Positive control
    • Mouse heart tissue lysate and hepatocarcinoma tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab37807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P 1/50 - 1/100.

Target

  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor antibody
    • Activin A receptor type II like 1 antibody
    • Activin A receptor, type II like kinase 1 antibody
    • Activin receptor like kinase 1 antibody
    • Activin receptor-like kinase 1 antibody
    • ACVL1_HUMAN antibody
    • ACVRL1 antibody
    • ACVRLK1 antibody
    • ALK-1 antibody
    • ALK1 antibody
    • HHT antibody
    • HHT2 antibody
    • ORW2 antibody
    • Osler Rendu Weber syndrome 2 antibody
    • Serine/threonine protein kinase receptor R3 antibody
    • Serine/threonine-protein kinase receptor R3 antibody
    • SKR3 antibody
    • TGF B superfamily receptor type I antibody
    • TGF-B superfamily receptor type I antibody
    • TSR-I antibody
    • TSR1 antibody
    see all

Anti-ACVRL1 antibody images

  • Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate

    Predicted band size : 56 kDa
    Observed band size : 56 kDa
    Additional bands at : 25 kDa,45 kDa,70 kDa. We are unsure as to the identity of these extra bands.
  • ab37807 at a 1/50 dilution detecting ACVRL1 expression in human hepatocarcinoma tissue (a peroxidase-conjugated secondary antibody, followed by AEC staining was used).

    These data demonstrate the suitability of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

References for Anti-ACVRL1 antibody (ab37807)

ab37807 has not yet been referenced specifically in any publications.

Product Wall

Thank you for calling.

As we discussed, I think you should try a different antibody, but no others have been tested for IHC on mouse tissue. I think ab68703 may be a good choice, even though it has not been tested for reactivity with mouse t...

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Thank you for contacting us. While I am unaware of any references describingACVRL1 expression in tumors, the human protein atlas (linked below) does show that "distinct cytoplasmic staining with a granular pattern was observed in thyroid cancers, ...

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