Anti-ACVRL1 antibody (ab74039)


  • Product nameAnti-ACVRL1 antibody
    See all ACVRL1 primary antibodies
  • Description
    Rabbit polyclonal to ACVRL1
  • SpecificityThis antibody detects endogenous levels of total ACVRL1 protein.
  • Tested applicationsSuitable for: WB, IHC-P, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    A synthesized peptide derived from the internal region of human ACVL1.

  • Positive control
    • Human breast carcinoma tissue sections, Hela cells and extracts from K562 cells.



Our Abpromise guarantee covers the use of ab74039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 56 kDa.
IHC-P 1/50 - 1/100.
ICC/IF 1/500 - 1/1000.
ELISA 1/20000.


  • FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • Involvement in diseaseDefects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activin A receptor antibody
    • Activin A receptor type II like 1 antibody
    • Activin A receptor, type II like kinase 1 antibody
    • Activin receptor like kinase 1 antibody
    • Activin receptor-like kinase 1 antibody
    • ACVL1_HUMAN antibody
    • ACVRL1 antibody
    • ACVRLK1 antibody
    • ALK-1 antibody
    • ALK1 antibody
    • HHT antibody
    • HHT2 antibody
    • ORW2 antibody
    • Osler Rendu Weber syndrome 2 antibody
    • Serine/threonine protein kinase receptor R3 antibody
    • Serine/threonine-protein kinase receptor R3 antibody
    • SKR3 antibody
    • TGF B superfamily receptor type I antibody
    • TGF-B superfamily receptor type I antibody
    • TSR-I antibody
    • TSR1 antibody
    see all

Anti-ACVRL1 antibody images

  • Immunohistochemical analysis of ACVRL1 in paraffin embedded human breast carcinoma tissue using ab74039 at a 1/50 dilution.
    Left image: untreated.
    Right image: treated with immunizing peptide.
  • All lanes : Anti-ACVRL1 antibody (ab74039) at 1/500 dilution

    Lane 1 : Extracts from K562 cells
    Lane 2 : Extracts from K562 cells with immunizing peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 56 kDa
    Observed band size : 56 kDa
  • Immunofluorescence analysis of ACVRL1 in HeLa cells using ab74039 at a 1/500 dilution.
    Left image: untreated.
    Right image: treated with immunizing peptide.

References for Anti-ACVRL1 antibody (ab74039)

ab74039 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (skin)
Specification skin
Fixative Paraformaldehyde
Antigen retrieval step Enzymatic - Buffer/Enzyme Used: Proteinase K
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: RT°C

Abcam user community

Verified customer

Submitted Jan 12 2012

Thank you for your e-mail. I am very sorry but we cannot provide individual aliquots to customers. While I understand the validity that the immunizing peptide would provide I do believe that you could prove your staining to be accurate by incubatin...

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Unfortunately we are not able to add this peptide to our catalogue at this time. I apologize for any inconvenience this may cause.

Thank you for your inquiry. Please check the following website which shows that ACVL1 is expressed in breast cancer: I hope this information is helpful to you. Please do not hesitate t...

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