Overview

  • Product name
    Acyclovir
  • Description
    Inhibits viral DNA polymerase. Antiherpetic agent.
  • Biological description
    Guanosine derivative, competitively inhibits viral DNA polymerase. High specificity for herpes simplex 1 and 2 (EC50 values are 0.04 and 0.44 μM, respectively) and varicella-zoster viruses (IC50 = 0.22 μM).
  • Purity
    > 99%

Properties

  • Chemical name
    2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
  • Molecular weight
    225.21
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C8H11N5O3
  • CAS Number
    59277-89-3
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in 1eq. HCl to 50 mM (with heating) and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • De Clercq E & Field HJ Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy. Br J Pharmacol 147:1-11 (2006). Read more (PubMed: 16284630) »
  • Suzuki M  et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res 72:157-61 (2006). Read more (PubMed: 16797734) »
  • Brand G  et al. The potency of acyclovir can be markedly different in different cell types. Life Sci 69:1285-90 (2001). Read more (PubMed: 11521752) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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