Inhibits viral DNA polymerase. Antiherpetic agent.
Biological descriptionGuanosine derivative, competitively inhibits viral DNA polymerase. High specificity for herpes simplex 1 and 2 (EC50 values are 0.04 and 0.44 μM, respectively) and varicella-zoster viruses (IC50 = 0.22 μM).
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1eq. HCl to 50 mM (with heating) and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
De Clercq E & Field HJ Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy. Br J Pharmacol147:1-11 (2006).
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Suzuki M et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res72:157-61 (2006).
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