Overview

  • Product nameAnti-ADAM19 antibody
    See all ADAM19 primary antibodies
  • Description
    Rabbit polyclonal to ADAM19
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 218 - 267 (VADYLEFQKN RRDQDATKHK LIEIANYVDK FYRSLNIRIA LVGLEVWTHG) of Human ADAM19 (NP_075525).

  • Positive control
    • Human fetal muscle lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 82 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. It has been cloned from mouse and human. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues. The Cytoplasmic domain of ADAM19, like ADAMs 9, 12 and 15, contains SH3 ligand domains, which are thought to interact with PKC-d, suggesting specific regulation routes for ADAM19. Also reported is a sequence of ADAM19 lacking the transmembrane and cytoplasmic domains, suggesting that a soluble form is produced. ADAM-19 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. The full length ADAM19 sequence codes for a 956 amino acid protein, containing a Type-I transmembrane domain, with a predicted mass is 105 kD. Two shorter sequences have been reported: a 918 amino acid sequence that differs at the carboxyterminal end, and the soluble form, a 538 amino acid version with predicted mass of 59.9 kD. Mouse ADAM19 sequence is 920 AA, predicted at 100.86 kD.
  • Cellular localizationCell Membrane. Type I membrane protein.
  • Database links
  • Alternative names
    • A disintegrin and metalloproteinase domain 19 (meltrin beta) antibody
    • A disintegrin and metalloproteinase domain 19 antibody
    • ADAM 19 antibody
    • ADAM metallopeptidase domain 19 antibody
    • Disintegrin and metalloproteinase domain containing protein 19 antibody
    • FKSG 34 antibody
    • FKSG34 antibody
    • MADDAM antibody
    • Meltrin beta antibody
    • Metalloprotease and disintegrin dentritic antigen marker antibody
    • Metalloprotease disintegrin meltrin beta antibody
    • MLTN B antibody
    • MLTNB antibody
    see all

Anti-ADAM19 antibody images

  • Anti-ADAM19 antibody (ab104800) at 1/1 dilution + Human fetal muscle lysate at 10 µg

    Predicted band size : 82 kDa

References for Anti-ADAM19 antibody (ab104800)

This product has been referenced in:
  • Marballi K  et al. Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings. PLoS One 7:e36431 (2012). WB ; Human . Read more (PubMed: 22590542) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"