Overview

  • Product name
  • Description
    Rabbit polyclonal to ADAM20
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide against internal sequence amino acid of Human ADAM20 (NP_003805.3) conjugated to KLH.

  • Positive control
    • Human Prostate, Human Testis

Properties

Applications

Our Abpromise guarantee covers the use of ab118612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 15 - 20 µg/ml.

Target

  • Function
    May be involved in sperm maturation and/or fertilization.
  • Tissue specificity
    Testis specific.
  • Sequence similarities
    Contains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • Domain
    A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
    The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • A disintegrin and metalloproteinase domain 20 antibody
    • A disintegrin and metalloproteinase domain 20 preproprotein antibody
    • ADA20_HUMAN antibody
    • ADAM 20 antibody
    • ADAM metallopeptidase domain 20 antibody
    • ADAM20 antibody
    • Disintegrin and metalloproteinase domain-containing protein 20 antibody
    • OTTHUMP00000236151 antibody
    see all

Images

  • ab118612 at 15 µg/ml staining ADAM20 in Formalin-fixed, Paraffin-embedded Human Prostate tissue by Immunohistochemistry.
  • ab118612 at 15 µg/ml staining ADAM20 in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry.

References

ab118612 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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