Recombinant
RabMAb

Anti-ADAMTS10 antibody [EPR11860] (ab173290)

Overview

  • Product name
    Anti-ADAMTS10 antibody [EPR11860]
    See all ADAMTS10 primary antibodies
  • Description
    Rabbit monoclonal [EPR11860] to ADAMTS10
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment within Human ADAMTS10. The exact sequence is proprietary.
    Database link: Q9H324

  • Positive control
    • Fetal heart and A549 lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab173290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 121 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
    • Tissue specificity
      Widely expressed in adult tissues.
    • Involvement in disease
      Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1) [MIM:277600]. WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
    • Sequence similarities
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 1 PLAC domain.
      Contains 5 TSP type-1 domains.
    • Domain
      The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    • Post-translational
      modifications
      Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
    • Cellular localization
      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • A disintegrin and metalloproteinase with thrombospondin motifs 10 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 antibody
      • A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 10 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 10 antibody
      • ADAM TS10 antibody
      • ADAM-TS 10 antibody
      • ADAM-TS10 antibody
      • ADAMTS-10 antibody
      • Adamts10 antibody
      • ATS10_HUMAN antibody
      • EC 3.4.24 antibody
      • WMS antibody
      • WMS1 antibody
      • zinc metalloendopeptidase antibody
      see all

    Images

    • All lanes : Anti-ADAMTS10 antibody [EPR11860] (ab173290) at 1/1000 dilution

      Lane 1 : Fetal heart lysate
      Lane 2 : A549 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 121 kDa

    References

    ab173290 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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