• Product nameAnti-ADAMTS13 antibody
    See all ADAMTS13 primary antibodies
  • Description
    Rabbit polyclonal to ADAMTS13
  • SpecificityThis antibody reacts specifically with human 154 kDa ADAMTS13 protein
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide derived from the N-terminal domain of ADAMTS13 protein.

  • Positive control
    • This antibody gave a positive signal in mouse liver tissue lysate.



Our Abpromise guarantee covers the use of ab71550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/500. Detects a band of approximately 154 kDa (predicted molecular weight: 154 kDa).


  • FunctionCleaves the vWF multimers in plasma into smaller forms.
  • Tissue specificityPlasma. Expressed primarily in liver.
  • Involvement in diseaseDefects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
  • Sequence similaritiesContains 2 CUB domains.
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 8 TSP type-1 domains.
  • DomainThe pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
    The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
  • Post-translational
    May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
    The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
    • ADAM TS antibody
    • ADAM-TS 13 antibody
    • ADAM-TS13 antibody
    • ADAMTS 13 antibody
    • ADAMTS-13 antibody
    • ADAMTS13 antibody
    • ADAMTS13 protein antibody
    • ATS13_HUMAN antibody
    • C9orf8 antibody
    • TTP antibody
    • Von Willebrand factor cleaving protease antibody
    • von Willebrand factor-cleaving protease antibody
    • vWF cleaving protease antibody
    • vWF CP antibody
    • vWF-cleaving protease antibody
    • vWF-CP antibody
    • vWFCP antibody
    see all

Anti-ADAMTS13 antibody images

  • Anti-ADAMTS13 antibody (ab71550) at 1/500 dilution + Liver (Mouse) Tissue Lysate at 10 µg

    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 154 kDa
    Observed band size : 154 kDa
    Additional bands at : 37 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 20 minutes

References for Anti-ADAMTS13 antibody (ab71550)

This product has been referenced in:
  • Bartoli CR  et al. Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support. J Thorac Cardiovasc Surg N/A:N/A (2013). WB . Read more (PubMed: 24139617) »
  • Pos W  et al. An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood 115:1640-9 (2010). WB ; Human . Read more (PubMed: 20032502) »

See all 2 Publications for this product

Product Wall

Application Western blot
Sample Mouse Cell lysate - whole cell (hepatocytes)
Gel Running Conditions Reduced Denaturing
Loading amount 20 µg
Specification hepatocytes
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C

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Submitted Sep 10 2015

Laut unseren Unterlagen hatten Sie Probleme mit ab71550 Anti-ADAMTS13 antibody und haben unseren technischen Dienst deswegen kontaktiert.

Ich sehe, dass wir noch auf einige Angaben hinsichtlich Ihrer Bestellung warten, die uns helfen werden ...

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I can confirm that ab71550 antibody is sold as whole antiserum. Unpurified antibodies, such as those sold as whole antiserum, ascites or tissue culture supernatant will not have a concentration stated on the datashe...

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