Overview

  • Product nameAnti-ADAMTS17 antibody
    See all ADAMTS17 primary antibodies
  • Description
    Mouse monoclonal to ADAMTS17
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 543-651 of Human ADAMTS17

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab58099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 121 kDa.Can be blocked with Recombinant Human ADAMTS17 protein (ab153619).
IHC-P Use at an assay dependent concentration. PubMed: 19836009

Target

  • Tissue specificityIsoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver.
  • Involvement in diseaseDefects in ADAMTS17 are the cause of Weill-Marchesani-like syndrome (WMLS) [MIM:613195]. It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 5 TSP type-1 domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • A disintegrin and metalloproteinase with thrombospondin motifs 17 antibody
    • A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif, 17 antibody
    • ADAM-TS 17 antibody
    • ADAM-TS17 antibody
    • ADAMTS 17 antibody
    • ADAMTS-17 antibody
    • ADAMTS17 antibody
    • ATS17_HUMAN antibody
    • EC 3.4.24. antibody
    • FLJ16363 antibody
    • FLJ32769 antibody
    • OTTHUMP00000194818 antibody
    see all

Anti-ADAMTS17 antibody images



  • Predicted band size : 121 kDa
    ADAMTS17 antibody (ab58099) at 1ug/lane + A-431 cell lysate at 25ug/lane.

References for Anti-ADAMTS17 antibody (ab58099)

This product has been referenced in:
  • Morales J  et al. Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Am J Hum Genet 85:558-68 (2009). WB, IHC-P ; Human . Read more (PubMed: 19836009) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"