The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 135 kDa.
Use at an assay dependent concentration. PubMed: 24343133
FunctionCleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.
Tissue specificityExpressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
Involvement in diseaseDefects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C) [MIM:225410]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome.
Predicted band size : 135 kDa ADAMTS2 antibody (ab56735) at 1ug/lane + PC-12 cell lysate at 25ug/lane.
References for Anti-ADAMTS2 antibody (ab56735)
This product has been referenced in:
Alarab M et al. Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic Organ Prolapse. Reprod SciN/A:N/A (2013).
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