Overview

  • Product nameAnti-ADAMTS2 antibody
    See all ADAMTS2 primary antibodies
  • Description
    Mouse monoclonal to ADAMTS2
  • Tested applicationsSuitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment: KHNDIDVFMP TLPVPTVAME VRPSPSTPLE VPLNASSTNA TEDHPETNAV DEPYKIHGLE DEVQPPNLIP RRPSPYEKTR NQRIQELIDE MRKKEMLGK, corresponding to amino acids 1112-1211 of Human ADAMTS2

Properties

Applications

Our Abpromise guarantee covers the use of ab56735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 135 kDa.
IHC-Fr Use at an assay dependent concentration. PubMed: 24343133

Target

  • FunctionCleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.
  • Tissue specificityExpressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
  • Involvement in diseaseDefects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C) [MIM:225410]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 4 TSP type-1 domains.
  • DomainThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody
    • ADAM TS 2 antibody
    • ADAM TS2 antibody
    • ADAM-TS 2 antibody
    • ADAM-TS2 antibody
    • ADAMTS 3 antibody
    • ADAMTS-2 antibody
    • ADAMTS2 antibody
    • ATS2_HUMAN antibody
    • EC 3.4.24.14 antibody
    • EDS VIIB antibody
    • EDS VIIC antibody
    • hPCPNI antibody
    • NPI antibody
    • PC I NP antibody
    • PC I-NP antibody
    • PCINP antibody
    • PCPNI antibody
    • pNPI antibody
    • Procollagen I N proteinase antibody
    • Procollagen I N-proteinase antibody
    • Procollagen I/II amino propeptide processing enzyme antibody
    • Procollagen I/II amino propeptide-processing enzyme antibody
    • Procollagen N endopeptidase antibody
    • Procollagen N-endopeptidase antibody
    see all

Anti-ADAMTS2 antibody images



  • Predicted band size : 135 kDa
    ADAMTS2 antibody (ab56735) at 1ug/lane + PC-12 cell lysate at 25ug/lane.

References for Anti-ADAMTS2 antibody (ab56735)

This product has been referenced in:
  • Alarab M  et al. Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic Organ Prolapse. Reprod Sci N/A:N/A (2013). WB, IHC-Fr ; Human . Read more (PubMed: 24343133) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"