Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab41235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Purity> 95 % by SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75

General info

  • Alternative names
    • A disintegrin and metalloproteinase with thrombospondin motifs 4
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 4
    • ADAM metallopeptidase with thrombospondin type 1 motif 4
    • ADAM TS 4
    • ADAM TS4
    • ADAM-TS 4
    • ADAM-TS4
    • ADAMTS 2
    • ADAMTS 4
    • ADAMTS-4
    • ADAMTS2
    • ADAMTS4
    • ADAMTS4 protein
    • ADMP 1
    • ADMP-1
    • ADMP1
    • Aggrecanase 1
    • Aggrecanase-1
    • Aggrecanase1
    • ATS4_HUMAN
    • KIAA0688
    see all
  • FunctionCleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • Tissue specificityExpressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • DomainThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Target information above from: UniProt accession O75173 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for ADAMTS4 peptide (ab41235)

ab41235 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"