Overview

  • Product name
  • Description
    Rabbit polyclonal to ADAMTS5
  • Specificity
    ab111918 is specific for ADAMTS5 and shows no cross-reactivity with other ADAMTS family members.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Cow, Human, Pig
    Predicted to work with: Mouse, Rat, Horse
  • Immunogen

    Synthetic peptide:

    KNGYQSDAKGVKTF

    (with a Cysteine residue linker), corresponding to amino acids 636-649 of Human ADAMTS5 (Q9UNA0)

  • Positive control
    • Porcine cartilage extract, Human recombinant ADAMTS5

Properties

Applications

Our Abpromise guarantee covers the use of ab111918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 102 kDa. This antibody detects a major band at ~68 kDa protein representing ADAMTS5 from porcine cartilage extract. On human recombinant ADAMTS5 this antibody detects a major band at ~85 kDa. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

Target

  • Function
    Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
  • Tissue specificity
    Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
  • Sequence similarities
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 2 TSP type-1 domains.
  • Domain
    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • A disintegrin and metalloproteinase with thrombospondin motifs 11 antibody
    • A disintegrin and metalloproteinase with thrombospondin motifs 5 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase 2) antibody
    • A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 5 antibody
    • A Disintigrin And Metalloproteinase with ThromboSpondin motif-5 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 5 antibody
    • ADAM TS 11 antibody
    • ADAM TS 5 antibody
    • ADAM TS5 antibody
    • ADAM-TS 11 antibody
    • ADAM-TS 5 antibody
    • ADAM-TS5 antibody
    • ADAMTS 11 antibody
    • ADAMTS 5 antibody
    • ADAMTS-11 antibody
    • ADAMTS-5 antibody
    • ADAMTS11 antibody
    • ADAMTS11, formerly antibody
    • Adamts5 antibody
    • ADMP 2 antibody
    • ADMP-2 antibody
    • ADMP2 antibody
    • Aggrecanase 2 antibody
    • Aggrecanase-2 antibody
    • ATS5_HUMAN antibody
    • FLJ36738 antibody
    • Implantin antibody
    • ThromboSpondin motif-5 antibody
    see all

References for Anti-ADAMTS5 antibody (ab111918)

ab111918 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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