Overview

  • Product nameAnti-ADAMTS8 antibody
  • Description
    Mouse monoclonal to ADAMTS8
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 781-891 of Human ADAMTS8

Properties

Applications

Our Abpromise guarantee covers the use of ab56923 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. A member of the metalloproteinase family containing disintegrin like domains (ADAMs), the function of ADAMTS8 is still poorly understood. ADAMTS8 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active on a range of substrates. ADAMTS8 is inhibited by the endogenous MMP inhibitors, TIMP1, 2, 3 and 4, but most efficiently by TIMP3. In addition to the metalloprotease domain, ADAMTS8 has a propeptide domain, a Prohormone Convertase (PC, furin) cleavage site, a cysteine rich domain and thrombospondin 1 like domains.
    • Cellular localizationSecreted protein; extracellular space; extracellular matrix.
    • Database links
    • Alternative names
      • A disintegrin and metalloproteinase with thrombospondin motifs 8 antibody
      • A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 8 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 8 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 8 antibody
      • ADAM TS 8 antibody
      • ADAM TS8 antibody
      • ADAMTS 8 antibody
      • FLJ41712 antibody
      • METH 2 antibody
      • METH 8 antibody
      • METH2 antibody
      • METH8 antibody
      see all

    Anti-ADAMTS8 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56923 ADAMTS8 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-ADAMTS8 antibody (ab56923)

    ab56923 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"