Tissue specificityExpressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon.
Post-translational modificationsGlycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
A disintegrin like and metalloprotease domain with thrombospondin type I motifs like 3 antibody
ADAMTS like 3 antibody
ADAMTS-like protein 3 antibody
Anti-ADAMTSL3 antibody images
Immunocytochemistry/ Immunofluorescence - Anti-ADAMTSL3 antibody (ab104507)This image is courtesy of an anonymous Abreview
ab104507 staining ADAMTSL3 in Mouse heart valve cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde and blocked with 0.02% serum for 30 minutes at 25°C. Samples were incubated with primary antibody (1/25) for 16 hour at 4°C. An Alexa Fluor®594-conjugated Goat anti-rabbit IgG polyclonal(1/200) was used as the secondary antibody.