Anti-Adducin (phospho T445) antibody (ab58485)

Overview

  • Product nameAnti-Adducin (phospho T445) antibody
    See all Adducin primary antibodies
  • Description
    Rabbit polyclonal to Adducin (phospho T445)
  • Specificityab58485 detects endogenous levels of Adducin only when phosphorylated at threonine 445.
  • Tested applicationsSuitable for: IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from human ADD1 around the phosphorylation site of threonine 445 (E-K-TP-R-W).

  • Positive control
    • Human breast carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab58485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ELISA 1/5000.

Target

  • RelevanceAdducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
  • Cellular localizationCytoplasm › cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • Database links
  • Alternative names
    • ADD1 antibody
    • ADD2 antibody
    • ADD3 antibody
    • ADDA antibody
    • ADDB antibody
    • ADDL antibody
    • Adducin 1 (alpha) antibody
    • Adducin 1 antibody
    • Adducin 2 (beta) antibody
    • Adducin 2 antibody
    • Adducin 3 (gamma) antibody
    • Adducin 3 antibody
    • Adducin like antibody
    • Alpha adducin antibody
    • Beta adducin antibody
    see all

Anti-Adducin (phospho T445) antibody images

  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab58485 at a dilution of 1/50. Right hand image: treated with immunising peptide. Left hand image: untreated.

References for Anti-Adducin (phospho T445) antibody (ab58485)

ab58485 has not yet been referenced specifically in any publications.

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