Anti-Adenomatous polyposis coli protein 2 antibody (ab106600)

Overview

  • Product name
    Anti-Adenomatous polyposis coli protein 2 antibody
    See all Adenomatous polyposis coli protein 2 primary antibodies
  • Description
    Rabbit polyclonal to Adenomatous polyposis coli protein 2
  • Specificity
    ab106600 is predicted to not cross-react with other Apc family members. At least four isoforms of Apc2 are known to exist.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human Apc2 (internal sequence).
    Database link: O95996

  • Positive control
    • HeLa cells and cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 244 kDa.
ICC Use a concentration of 5 µg/ml.

Target

  • Function
    Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
  • Tissue specificity
    Widely expressed (at protein level). Specifically expressed in the CNS.
  • Sequence similarities
    Belongs to the adenomatous polyposis coli (APC) family.
    Contains 6 ARM repeats.
  • Developmental stage
    Expressed in fetal brain.
  • Cellular localization
    Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Associated with actin filaments (PubMed:11691822). Associated with microtubule network (PubMed:10644998, PubMed:11691822).
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenomatous polyposis coli protein 2 antibody
    • Adenomatous polyposis coli protein-like antibody
    • APC-like antibody
    • apc2 antibody
    • APC2_HUMAN antibody
    • APCL antibody
    see all

Images

  • Immunofluorescence of Apc2 in HeLa cells with ab106600 at 20 ug/mL.

  • Lane 1 : Anti-Adenomatous polyposis coli protein 2 antibody (ab106600) at 1 µg/ml
    Lane 2 : Anti-Adenomatous polyposis coli protein 2 antibody (ab106600) at 2 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 244 kDa
  • Immunocytochemical analysis of ab106600 at 5 µg/ml in HeLa cells.

References

ab106600 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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