Anti-Adenylosuccinate Lyase antibody (ab67516)

Overview

  • Product nameAnti-Adenylosuccinate Lyase antibody
    See all Adenylosuccinate Lyase primary antibodies
  • Description
    Mouse polyclonal to Adenylosuccinate Lyase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human)

  • Positive control
    • Adenylosuccinate Lyase transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab67516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).

Target

  • Tissue specificityUbiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.
  • PathwayPurine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
    Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.
  • Involvement in diseaseDefects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) [MIM:103050]. ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present.
  • Sequence similaritiesBelongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenylosuccinase antibody
    • Adenylosuccinate lyase antibody
    • ADSL antibody
    • AMPS antibody
    • ASase antibody
    • ASL antibody
    • OTTHUMP00000199172 antibody
    • OTTHUMP00000199173 antibody
    • PUR8_HUMAN antibody
    see all

Anti-Adenylosuccinate Lyase antibody images

  • All lanes : Anti-Adenylosuccinate Lyase antibody (ab67516) at 1/500 dilution

    Lane 1 : Adenylosuccinate Lyase transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

    Predicted band size : 55 kDa
    Observed band size : 55 kDa

References for Anti-Adenylosuccinate Lyase antibody (ab67516)

ab67516 has not yet been referenced specifically in any publications.

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