Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionReceptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
Tissue specificityWidely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
Sequence similaritiesBelongs to the ADIPOR family.
DomainThe N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Cellular localizationMembrane. Localized to the cell membrane and intracellular organelles.
Paraffin section of human muscle tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.
References for Anti-Adiponectin Receptor 1 antibody (ab77611)
This product has been referenced in:
Basu S et al. Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. PLoS One10:e0138443 (2015).
Read more (PubMed: 26431176) »