FunctionReceptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
Tissue specificityHighly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
Sequence similaritiesBelongs to the ADIPOR family.
DomainThe N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Cellular localizationMembrane. Localized to the cell membrane and intracellular organelles.