Anti-Adiponectin Receptor 2 antibody (ab77613)

Overview

  • Product name
    Anti-Adiponectin Receptor 2 antibody
    See all Adiponectin Receptor 2 primary antibodies
  • Description
    Goat polyclonal to Adiponectin Receptor 2
  • Specificity
    Recognizes ADPR2 Receptor. Likely to cross react with ADPR1 Receptor.
  • Tested applications
    Suitable for: WB, IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human, Macaque monkey
    Predicted to work with: Chicken, Cow, Pig
  • Immunogen

    Synthetic peptide:

    YITGAALYAARIPERFFPGKC

    , corresponding to C terminal amino acids 321-341 of human Adiponectin Receptor 2

  • Positive control
    • Human liver tissue and human muscle tissue
  • General notes


    This antibody may be used in developing sandwitch ELISA assays in combination with antibodies specific to N terminus of ADPR2 Receptor.

Applications

Our Abpromise guarantee covers the use of ab77613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 44 kDa.
IHC-P 1/250.

Buffer used: 10 mM KHPO4, 140 mM NaCl, pH 7.2.

ICC 1/400.

Acetone fixed cells.

Target

  • Function
    Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
  • Tissue specificity
    Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
  • Sequence similarities
    Belongs to the ADIPOR family.
  • Domain
    The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
  • Cellular localization
    Membrane. Localized to the cell membrane and intracellular organelles.
  • Information by UniProt
  • Database links
  • Alternative names
    • PAQR2 antibody
    • ACDCR2 antibody
    • Adiponectin receptor protein 2 antibody
    • Adipor2 antibody
    • ADR2_HUMAN antibody
    • Progestin and adipoQ receptor family member II antibody
    see all

Images

  • Paraffin section of human liver tissue stained with antibody to human ADPR2 receptor C-terminus ab77613 at 1/250 dilution.
  • Paraffin section of human muscle tissue stained with antibody to human ADPR2 receptor C-terminus ab77613 at 1/250 dilution.

References

ab77613 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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