Anti-Adiponectin Receptor 2 antibody - Aminoterminal end (ab53399)

Overview

  • Product name
    Anti-Adiponectin Receptor 2 antibody - Aminoterminal end
    See all Adiponectin Receptor 2 primary antibodies
  • Description
    Goat polyclonal to Adiponectin Receptor 2 - Aminoterminal end
  • Tested applications
    Suitable for: WB, ICC, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide:

    CSRTPEPDIRLRKGHQLDGTRRGDNDSHQG

    , corresponding to N terminal amino acids 11-40 of Human Adiponectin Receptor 2

  • Positive control
    • Human liver; human muscle;

Applications

Our Abpromise guarantee covers the use of ab53399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 44 kDa.
ICC 1/400.
IHC-P Use at an assay dependent dilution.

Target

  • Function
    Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
  • Tissue specificity
    Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
  • Sequence similarities
    Belongs to the ADIPOR family.
  • Domain
    The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
  • Cellular localization
    Membrane. Localized to the cell membrane and intracellular organelles.
  • Information by UniProt
  • Database links
  • Alternative names
    • PAQR2 antibody
    • ACDCR2 antibody
    • Adiponectin receptor protein 2 antibody
    • Adipor2 antibody
    • ADR2_HUMAN antibody
    • Progestin and adipoQ receptor family member II antibody
    see all

Images

  • IH paraffin section human liver with ab53399 at a dilution of 1/250.
  • IH paraffin section human muscle with ab53399 at a dilution of 1/250.

References

This product has been referenced in:
  • Fang F  et al. Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways. Am J Physiol Renal Physiol 304:F1366-74 (2013). Read more (PubMed: 23535586) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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