Anti-Adipose Triglyceride Lipase antibody (ab57562)

Overview

  • Product nameAnti-Adipose Triglyceride Lipase antibody
    See all Adipose Triglyceride Lipase primary antibodies
  • Description
    Mouse monoclonal to Adipose Triglyceride Lipase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: SFTIRLLEWL PDVPEDIRWM KEQTGSICQY LVMRAKRKLG RHLPSRLPEQ VELRRVQSLP SVPLSCAAYR EALPGWMRNN LSLGDALAKW EECQRQLLLG , corresponding to amino acids 347-447 of Human Adipose Triglyceride Lipase

Properties

Applications

Our Abpromise guarantee covers the use of ab57562 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCatalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
    • Tissue specificityHighest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).
    • PathwayGlycerolipid metabolism; triacylglycerol degradation.
    • Involvement in diseaseNote=Genetic variations in PNPLA2 may be associated with risk of diabetes mellitus type 2.
      Defects in PNPLA2 are the cause of neutral lipid storage disease with myopathy (NLSDM) [MIM:610717]; also known as neutral lipid storage disease without ichthyosis. NSLDM is a neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.
    • Sequence similaritiesContains 1 patatin domain.
    • Developmental stageInduced during differentiation of primary preadipocytes to adipocytes. Expression increased from fetal to adult in retinal pigment epithelium.
    • Cellular localizationLipid droplet. Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1110001C14Rik antibody
      • Adipose triglyceride lipase antibody
      • ATGL antibody
      • ATGL DESNUTRIN antibody
      • Calcium independent phospholipase A2 antibody
      • Calcium-independent phospholipase A2 antibody
      • Desnutrin antibody
      • EC 3.1.1.3 antibody
      • FP17548 antibody
      • IPLA2 zeta antibody
      • IPLA2-zeta antibody
      • PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2 antibody
      • Patatin-like phospholipase domain-containing protein 2 antibody
      • PEDF R antibody
      • PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA antibody
      • Pigment epithelium derived factor antibody
      • Pigment epithelium-derived factor antibody
      • plpl antibody
      • plpl2 antibody
      • PLPL2_HUMAN antibody
      • Pnpla2 antibody
      • Transport secretion protein 2 antibody
      • Transport secretion protein 2.2 antibody
      • Transport-secretion protein 2 antibody
      • Triglyceride hydrolase antibody
      • TTS 2.2 antibody
      • TTS2 antibody
      • TTS2.2 antibody
      • ZETA antibody
      see all

    Anti-Adipose Triglyceride Lipase antibody images

    • Western blot against tagged recombinant protein immunogen using ab57562 Adipose Triglyceride Lipase antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-Adipose Triglyceride Lipase antibody (ab57562)

    ab57562 has not yet been referenced specifically in any publications.

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