Overview

  • Product nameAnti-AF10 antibody [HAF10 9A5/2]
    See all AF10 primary antibodies
  • Description
    Mouse monoclonal [HAF10 9A5/2] to AF10
  • Tested applicationsSuitable for: WB, ELISA, Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    RLSDKTGPVAQEKS

    , corresponding to amino acids 1055-1069 of Human AF10

Properties

Applications

Our Abpromise guarantee covers the use of ab16968 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 110 kDa.
ELISA Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

Target

  • FunctionProbably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.
  • Tissue specificityExpressed abundantly in testis.
  • Involvement in diseaseA chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
    A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
  • Sequence similaritiesContains 1 C2HC pre-PHD-type zinc finger.
    Contains 2 PHD-type zinc fingers.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AF 10 antibody
    • AF10 antibody
    • AF10_HUMAN antibody
    • ALL 1 fused gene from chromosome 10 antibody
    • ALL1 fused gene from chromosome 10 antibody
    • ALL1-fused gene from chromosome 10 protein antibody
    • DKFZp686E10210 antibody
    • MGC75086 antibody
    • MLLT 10 antibody
    • MLLT10 antibody
    • Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 10 antibody
    • Myeloid/lymphoid or mixed lineage leukemia translocated to 10 antibody
    • OTTHUMP00000045273 antibody
    • Protein AF 10 antibody
    • Protein AF-10 antibody
    • Protein AF10 antibody
    • Type I AF10 protein antibody
    see all

References for Anti-AF10 antibody [HAF10 9A5/2] (ab16968)

This product has been referenced in:
  • Chamorro-Garcia R  et al. AF10 plays a key role in the survival of uncommitted hematopoietic cells. PLoS One 7:e51626 (2012). WB ; Mouse . Read more (PubMed: 23284727) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. The epitope that both ab16968 and ab16969 react with is aa 1055-1069, RLSDKTGPVAQEKS. This epitope is 100% identical in human and mouse proteins It appears that these antibodies will also recognise the mouse protein s...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"