This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

Target

  • Involvement in disease
    Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.
  • Sequence similarities
    Belongs to the AF4 family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AF 4 antibody
    • AF 4 protein antibody
    • AF4 antibody
    • AF4-MLL antibody
    • AF4/FMR2 family member 1 antibody
    • AFF 1 antibody
    • AFF1 antibody
    • AFF1_HUMAN antibody
    • ALL1 fused gene from chromosome 4 antibody
    • ALL1-fused gene from chromosome 4 protein antibody
    • FEL antibody
    • MGC134969 antibody
    • MLL/AF4 antibody
    • MLLT2 antibody
    • myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 antibody
    • MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2 antibody
    • PBM1 antibody
    • Pre B cell monocytic leukemia partner 1 antibody
    • Protein AF-4 antibody
    • Protein FEL antibody
    • Proto-oncogene AF4 antibody
    see all

References

This product has been referenced in:
  • Ahmad K  et al. Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. Oncogenesis 3:e127 (2014). ChIP . Read more (PubMed: 25402609) »
  • Wilkinson AC  et al. RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep 3:116-27 (2013). WB, ChIP, CHIPseq ; Human . Read more (PubMed: 23352661) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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