The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 95 kDa.
FunctionGTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.
DomainThe PH domain mediates AP-3 binding.
Post-translational modificationsPhosphorylated on tyrosines.
Cellular localizationCytoplasm. Associates with the endocytic compartment.