Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Contains 1 Arf-GAP domain.
Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.
Detection of AGFG1 by Western Blot of Immunprecipitate.
ab86349 at 1µg/ml staining AGFG1 in HeLa whole cell lysate immunoprecipitated using ab86349 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 3 seconds.