Overview

  • Product nameAnti-Aggrecan antibody [Cat-315]
    See all Aggrecan primary antibodies
  • Description
    Mouse monoclonal [Cat-315] to Aggrecan
  • Tested applicationsSuitable for: ICC, WB, IP, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Rat, Cat
  • Immunogen

    Feline brain proteoglycans

  • EpitopeProtein core
  • Positive control
    • Primary cultured Rat cortical cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab78292 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC
WB
IP
IHC-FoFr
  • Application notesICC: 1/500, using primary cultures of neurons.
    IHC-FoFr: 1/2000.
    IP: Use at an assay dependent dilution.
    WB: 1/5000. Detects a band of approximately 680 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceAggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
    • Cellular localizationSecreted; extracellular matrix.
    • Database links
    • Alternative names
      • ACAN antibody
      • AGC 1 antibody
      • AGC1 antibody
      • AGCAN antibody
      • Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) antibody
      • Aggrecan 1 antibody
      • Aggrecan core protein antibody
      • Aggrecan proteoglycan antibody
      • Aggrecan structural proteoglycan of cartilage antibody
      • Aggrecan1 antibody
      • ATEGQV antibody
      • Cartilage specific proteoglycan core protein antibody
      • Chondroitin sulfate proteoglycan 1 antibody
      • Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122 antibody
      • Chondroitin sulfate proteoglycan core protein 1 antibody
      • CSPG 1 antibody
      • CSPG1 antibody
      • CSPGCP antibody
      • JSCATE antibody
      • Large aggregating proteoglycan antibody
      • mcspg antibody
      • mgsk16 antibody
      • MSK 16 antibody
      • MSK16 antibody
      • SEDK antibody
      see all

    Anti-Aggrecan antibody [Cat-315] images

    • Immunocytochemistry analysis of Rat primary cortical culture cells, using 1/500 ab78292.

    References for Anti-Aggrecan antibody [Cat-315] (ab78292)

    This product has been referenced in:
    • Lander C  et al. Neurons produce a neuronal cell surface-associated chondroitin sulfate proteoglycan. J Neurosci 18:174-83 (1998). WB, ICC, IP ; Rat . Read more (PubMed: 9412498) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"