Overview

  • Product name
  • Description
    Goat polyclonal to AGRP
  • Specificity
    This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531).
  • Tested applications
    Suitable for: IHC-FoFrmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide:

    (C)RKLGTAMNPCSRT

    , corresponding to C terminal amino acids 120-132 of Human AGRP

Properties

Applications

Our Abpromise guarantee covers the use of ab32882 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use a concentration of 0.05 - 0.1 µg/ml.

Target

  • Function
    Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • Tissue specificity
    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • Involvement in disease
    Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • Sequence similarities
    Contains 1 agouti domain.
  • Domain
    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • Cellular localization
    Secreted. Golgi apparatus lumen.
  • Information by UniProt
  • Database links
  • Alternative names
    • Agouti related neuropeptide antibody
    • Agouti Related Protein Homolog antibody
    • Agouti-related protein antibody
    • Agrp antibody
    • AGRP_HUMAN antibody
    • AGRT antibody
    • ART antibody
    • ASIP2 antibody
    see all

Images

  • Immunohistochemical analysis of PFA-perfused frozen Human hypothalamus tissue, staining AGRP with ab32882 at 0.05 µg/ml. Antigen retrieval was performed by heat mediation in a citrate buffer (pH 6).

References

ab32882 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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