Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceCRKLGTAMNPCSRT
    • Amino acids120 to 132

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45721 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-AGRP antibody (ab32882)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • Agouti related neuropeptide
    • Agouti Related Protein Homolog
    • Agouti-related protein
    • Agrp
    • AGRP_HUMAN
    • AGRT
    • ART
    • ASIP2
    see all
  • FunctionPlays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • Tissue specificityExpressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • Involvement in diseaseGenetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • Sequence similaritiesContains 1 agouti domain.
  • DomainThe presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • Cellular localizationSecreted. Golgi apparatus lumen.
  • Information by UniProt

References for AGRP peptide (120-132) (ab45721)

ab45721 has not yet been referenced specifically in any publications.

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The molecular weight of the AGRP peptide (120-132) (ab45721) is 1537.87 g/mol. This therefore equates to 1537870 mg/mol.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"