Overview

  • Product name
    Anti-AGXT antibody [AT2T4]
    See all AGXT primary antibodies
  • Description
    Mouse monoclonal [AT2T4] to AGXT
  • Tested applications
    Suitable for: ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Common marmoset, Orangutan
  • Immunogen

    Recombinant fragment: YDWRDIVSYV IDHFDIEIMG GLGPSTGKVL RIGLLGCNAT RENVDRVTEA LRAALQHCPK KKL, corresponding to amino acids 330-392 of Human AGXT, purified from E. coli (NP_000021).

  • Positive control
    • Human HeLa cells
  • General notes
    Derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant Human AGXT fragment.

Properties

Applications

Our Abpromise guarantee covers the use of ab95452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
ICC/IF 1/500 - 1/1000.

Target

  • Tissue specificity
    Liver.
  • Involvement in disease
    Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1) [MIM:259900]; also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.
  • Sequence similarities
    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
  • Cellular localization
    Peroxisome. Mitochondrion matrix. Except in some HP1 patients where AGT is found in the mitochondrial matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • AGT antibody
    • AGT1 antibody
    • Agxt antibody
    • AGXT1 antibody
    • Alanine glyoxylate aminotransferase antibody
    • Alanine glyoxylate aminotransferase3 antibody
    • Alanine--glyoxylate aminotransferase antibody
    • EC 2.6.1.44 antibody
    • EC 2.6.1.51 antibody
    • Hepatic peroxisomal alanine glyoxylate aminotransferase antibody
    • Hepatic peroxisomal alanine:glyoxylate aminotransferase antibody
    • L alanine glyoxylate aminotransferase 1 antibody
    • MS773 antibody
    • PH1 antibody
    • Serine pyruvate aminotransferase antibody
    • Serine--pyruvate aminotransferase antibody
    • Serine--pyruvate aminotransferase, mitochondrial antibody
    • Serine:pyruvate aminotransferase antibody
    • SPAT antibody
    • SPT antibody
    • SPYA_HUMAN antibody
    • TLH6 antibody
    see all

Images

  • Immunofluorescence of Human HeLa cells stained with PI (Red) and ab95452 (1:500) with Alexa 488 (Green).

References

ab95452 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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