Overview

  • Product nameAnti-AHI1 antibody
    See all AHI1 primary antibodies
  • Description
    Rabbit polyclonal to AHI1
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 25-75 of Human AHI1 according to NP_001128302.1.

  • Positive control
    • Whole cell lysate from HeLa cells.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH 7-8
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab117815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • Tissue specificityHighly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level).
    • Involvement in diseaseDefects in AHI1 are the cause of Joubert syndrome type 3 (JBTS3) [MIM:608629]. JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS3 shows minimal extra central nervous system involvement and appears not to be associated with renal dysfunction.
    • Sequence similaritiesContains 1 SH3 domain.
      Contains 7 WD repeats.
    • Cellular localizationCytoplasm > cytoskeleton > cilium basal body. Cell junction > adherens junction.
    • Information by UniProt
    • Database links
    • Alternative names
      • Abelson helper integration site 1 antibody
      • Abelson helper integration site 1 protein homolog antibody
      • Abelson helper integration site antibody
      • AHI 1 antibody
      • AHI-1 antibody
      • Ahi1 antibody
      • AHI1_HUMAN antibody
      • Contatins SH3 and WD40 domains antibody
      • dJ71N10.1 antibody
      • DKFZp686J1653 antibody
      • FLJ14023 antibody
      • FLJ20069 antibody
      • JBTS3 antibody
      • Jouberin antibody
      • ORF1 antibody
      • OTTHUMP00000017263 antibody
      • OTTHUMP00000017265 antibody
      • OTTHUMP00000234456 antibody
      • OTTHUMP00000234654 antibody
      • OTTHUMP00000234656 antibody
      see all

    Anti-AHI1 antibody images

    • Detection of AHI1 by Western Blot of Immunprecipitate.
      An antibody to AHI1 at 1µg/ml staining AHI1 in HeLa whole cell lysate.
      Lane 1; Immunoprecipitated using ab117815 at 6µg/mg lysate.
      Lane 2; Immunoprecipitated using control IgG.
      1 mg of lysate was used for IP and 20% of IP was loaded. Detection utilised Chemiluminescence with a 3 second exposure.

    References for Anti-AHI1 antibody (ab117815)

    ab117815 has not yet been referenced specifically in any publications.

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