Overview

  • Product nameAnti-AHI1 antibody
    See all AHI1 primary antibodies
  • Description
    Rabbit polyclonal to AHI1
  • Tested applicationsSuitable for: IHC-P, IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of human AHI1 protein.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab76843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/500.
IHC-Fr 1/50 - 1/500.
WB 1/200 - 1/2000. Predicted molecular weight: 137 kDa.

Target

  • Tissue specificityHighly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level).
  • Involvement in diseaseDefects in AHI1 are the cause of Joubert syndrome type 3 (JBTS3) [MIM:608629]. JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS3 shows minimal extra central nervous system involvement and appears not to be associated with renal dysfunction.
  • Sequence similaritiesContains 1 SH3 domain.
    Contains 7 WD repeats.
  • Cellular localizationCytoplasm > cytoskeleton > cilium basal body. Cell junction > adherens junction.
  • Information by UniProt
  • Database links
  • Alternative names
    • Abelson helper integration site 1 antibody
    • Abelson helper integration site 1 protein homolog antibody
    • Abelson helper integration site antibody
    • AHI 1 antibody
    • AHI-1 antibody
    • Ahi1 antibody
    • AHI1_HUMAN antibody
    • Contatins SH3 and WD40 domains antibody
    • dJ71N10.1 antibody
    • DKFZp686J1653 antibody
    • FLJ14023 antibody
    • FLJ20069 antibody
    • JBTS3 antibody
    • Jouberin antibody
    • ORF1 antibody
    • OTTHUMP00000017263 antibody
    • OTTHUMP00000017265 antibody
    • OTTHUMP00000234456 antibody
    • OTTHUMP00000234654 antibody
    • OTTHUMP00000234656 antibody
    see all

References for Anti-AHI1 antibody (ab76843)

ab76843 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"