Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Tissue specificityHighly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level).
Involvement in diseaseDefects in AHI1 are the cause of Joubert syndrome type 3 (JBTS3) [MIM:608629]. JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS3 shows minimal extra central nervous system involvement and appears not to be associated with renal dysfunction.
Western blot of Immunprecipitates using ab93386 at 2µg/800µg lysate.
Lane 1: Parental BaF3 cells
Lane 2: BaF3 + BCR-ABL (BaF3 cells transduced with BCR-ABL)
Lane 3: BaF3 + BCR-ABL + ab93386 (M1, BaF3 cells transduced with both BCR-ABL and ab93386, (M1 is a clonal cell line))
Lane 4: BaF3 + BCR-ABL + ab93386 (C2, BaF3 cells transduced with both BCR-ABL and ab93386, (C2 is a clonal cell line))
References for Anti-AHI1 antibody [M5] (ab93386)
This product has been referenced in:
Lee YL et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. Mol Biol Cell25:2919-33 (2014).
Read more (PubMed: 25103236) »