Overview

  • Product name
  • Description
    Rabbit polyclonal to AHRR
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide from the N terminal region of Human AHRR.

  • Positive control
    • Human fetal testis tissue. Human fetal lung, testis and spleen lysates.

Properties

  • Form
    Lyophilised:Reconstitute with 200ul distilled H2O. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 1% BSA, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab108518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Predicted molecular weight: 76 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function
    Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
  • Tissue specificity
    Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
  • Sequence similarities
    Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • Cellular localization
    Cytoplasm. Nucleus. Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
  • Information by UniProt
  • Database links
  • Alternative names
    • AHH antibody
    • AhR repressor antibody
    • AhRR antibody
    • AHRR_HUMAN antibody
    • aryl hydrocarbon hydroxylase regulator antibody
    • aryl hydrocarbon receptor regulator antibody
    • Aryl hydrocarbon receptor repressor antibody
    • Arylhydrocarbon receptor repressor antibody
    • bHLHe77 antibody
    • Class E basic helix-loop-helix protein 77 antibody
    • Dioxin receptor repressor antibody
    • KIAA1234 antibody
    • MGC167813 antibody
    • MGC176630 antibody
    • OTTHUMP00000221488 antibody
    • OTTHUMP00000221489 antibody
    see all

Anti-AHRR antibody images

  • All lanes : Anti-AHRR antibody (ab108518) at 1/1000 dilution

    Lane 1 : Fetal testis lysate
    Lane 2 : Fetal lung lysate
    Lane 3 : Fetal spleen lysate


    Predicted band size : 76 kDa
  • ab108518 at 1/100 dilution showing cytoplasmic and nuclear staining of AHRR in formalin-fixed, paraffin-embedded Human fetal testis by Immunohistochemistry.

References for Anti-AHRR antibody (ab108518)

ab108518 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your interest in ab108518. All of the information we currently have regarding this antibody is available on our online datasheet. At this time, no one has reported the use of this product to us in T-cells. However, we guarantee this ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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