Overview

  • Product nameAnti-AIBZIP antibody
    See all AIBZIP primary antibodies
  • Description
    Goat polyclonal to AIBZIP
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cynomolgus Monkey
  • Immunogen

    Synthetic peptide:

    C-PSGRIRSVLHADEM

    , corresponding to C terminal amino acids 382-395 of Human AIBZIP.

  • Positive control
    • Human prostate tissue; Human placenta lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab115466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 43 kDa.
ELISA 1/32000.
IHC-P Use a concentration of 2.5 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionTranscriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.
  • Tissue specificityAccording to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
  • Sequence similaritiesBelongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • Post-translational
    modifications
    N-glycosylated in the C-terminal region.
    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region.
  • Cellular localizationNucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. May also be located in Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1700012K17Rik antibody
    • AIbZIP antibody
    • Androgen induced basic leucine zipper antibody
    • Androgen induced basic leucine zipper protein antibody
    • Androgen-induced basic leucine zipper protein antibody
    • ATCE1 antibody
    • Attaching to CRE like 1 antibody
    • Attaching to CRE-like 1 antibody
    • cAMP responsive element binding protein 1 antibody
    • cAMP responsive element binding protein 3 like 4 antibody
    • cAMP responsive element binding protein 4 antibody
    • cAMP responsive element-binding protein 3 like protein 4 antibody
    • cAMP-responsive element-binding protein 3-like protein 4 antibody
    • cAMP-responsive element-binding protein 4 antibody
    • CR3L4_HUMAN antibody
    • CREB 4 antibody
    • CREB-4 antibody
    • CREB3 antibody
    • CREB3L4 antibody
    • CREB4 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 4 antibody
    • Cyclic AMP responsive element binding protein 4 antibody
    • Cyclic AMP-responsive element-binding protein 4 antibody
    • hJAL antibody
    • JAL antibody
    • mJAL antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 4 antibody
    • Tisp40 antibody
    • Tisp40alpha antibody
    • Tisp40beta antibody
    • Transcript induced in spermiogenesis protein 40 antibody
    see all

Anti-AIBZIP antibody images

  • ab115466, at 5 µg/ml, staining AIBZIP in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry.
  • Anti-AIBZIP antibody (ab115466) at 0.5 µg/ml + Human placenta lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 43 kDa


    Exposure time : 1 hour

References for Anti-AIBZIP antibody (ab115466)

ab115466 has not yet been referenced specifically in any publications.

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