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AICAR (Acadesine/AICA riboside)

Product code: ab120358 (formerly Asc-358)

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Overview

Product name

AICAR (Acadesine/AICA riboside)

Description

Cell-permeable activator of AMP-activated protein kinase

Alternative names

  • Acadesine
  • AICA riboside

Biological description

Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide

Molecular Weight

258.23

Chemical structure

Chemical Structure

Molecular formula

C9H14N4O5

CAS Number

2627-69-2

Solubility

Soluble in water

Storage instructions

Store at -20°C (desiccating conditions).

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Kinase >> AMP-kinase >> Activators
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water

References for AICAR (Acadesine/AICA riboside) (ab120358)

This product has been referenced in:

See all 5 publications for this product

Publishing research using ab120358? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"