AICAR (Acadesine/AICA riboside) (aqueous solution) (ab146594)

Overview

  • Product name
    AICAR (Acadesine/AICA riboside) (aqueous solution)
  • Description
    Cell-permeable activator of AMP-activated protein kinase
  • Biological description
    Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.

    Also available as a solid (ab120358).
  • Purity
    > 98%

Properties

  • Chemical name
    5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide
  • Molecular weight
    258.23
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C9H14N4O5
  • CAS Number
    2627-69-2
  • PubChem identifier
    17513
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Supplied in water (250 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    NC(=O)c2ncn([C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O)c2N
  • Source

    Synthetic

References

ab146594 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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