Overview

  • Product name
    Anti-AICDA antibody [mAID-2]
    See all AICDA primary antibodies
  • Description
    Rat monoclonal [mAID-2] to AICDA
  • Host species
    Rat
  • Tested applications
    Suitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control
    • Human tonsil tissue; Mouse intestinal Peyer's patches cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab169522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 20 µg/ml. Predicted molecular weight: 24 kDa.
IHC-P Use a concentration of 20 µg/ml.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function
    RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
  • Tissue specificity
    Strongly expressed in lymph nodes and tonsils.
  • Involvement in disease
    Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
  • Sequence similarities
    Belongs to the cytidine and deoxycytidylate deaminase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activation induced cytidine deaminase antibody
    • Activation induced deaminase antibody
    • Activation-induced cytidine deaminase antibody
    • AICDA antibody
    • AICDA_HUMAN antibody
    • AID antibody
    • ARP 2 antibody
    • ARP2 antibody
    • CDA 2 antibody
    • CDA2 antibody
    • Cytidine aminohydrolase antibody
    • HIGM2 antibody
    • Integrated into Burkitt's lymphoma cell line Ramos antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling N-methyl-D-aspartate receptor NR1 subunit with ab169522 at 20μg/ml, followed by Anti-Rat Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.

References

ab169522 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab169522.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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