The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 20 µg/ml. Predicted molecular weight: 24 kDa.
Use a concentration of 20 µg/ml.
Use at an assay dependent concentration.
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
Strongly expressed in lymph nodes and tonsils.
Involvement in disease
Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
Belongs to the cytidine and deoxycytidylate deaminase family.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling N-methyl-D-aspartate receptor NR1 subunit with ab169522 at 20μg/ml, followed by Anti-Rat Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.