Overview

  • Product nameAnti-AIMP2/p38 antibody
    See all AIMP2/p38 primary antibodies
  • Description
    Rabbit polyclonal to AIMP2/p38
  • Tested applicationsSuitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 2-172 of Human AIMP2/p38 (AAH02853).

  • Positive control
    • HCT116, HeLa and A549 cell lines; and HepG2 whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab101840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration. PubMed: 24312579
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

Target

  • FunctionRequired for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
  • Sequence similaritiesContains 1 GST C-terminal domain.
  • Post-translational
    modifications
    Phosphorylated on serine residues in response to UV irradiation.
    Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • Cellular localizationCytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aimp2 antibody
    • AIMP2_HUMAN antibody
    • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
    • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
    • ARS interacting multi functional protein 2 antibody
    • JTV 1 antibody
    • JTV 1 protein antibody
    • JTV1 antibody
    • JTV1 gene antibody
    • Multisynthase complex auxiliary component p38 antibody
    • Multisynthetase complex auxiliary component p38 antibody
    • P38 antibody
    • PRO0992 antibody
    • Protein JTV 1 antibody
    • Protein JTV-1 antibody
    • tRNA SYNTHETASE COFACTOR p38 antibody
    see all

Anti-AIMP2/p38 antibody images

  • Anti-AIMP2/p38 antibody (ab101840) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 35 kDa
    10% SDS PAGE

References for Anti-AIMP2/p38 antibody (ab101840)

This product has been referenced in:
  • Park SJ  et al. Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography. PLoS One 10:e0142253 (2015). WB ; Human . Read more (PubMed: 26544075) »
  • Kim K  et al. Reinvestigation of aminoacyl-TRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. PLoS One 8:e81734 (2013). WB, IP ; Human . Read more (PubMed: 24312579) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"