Overview

  • Product nameAnti-AIMP2/p38 antibody
    See all AIMP2/p38 primary antibodies
  • Description
    Rabbit polyclonal to AIMP2/p38
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide from internal sequence amino acids of Human AIMP2/p38.

  • Positive control
    • Rat liver, lung, kidney, and brain lysates; Jurkat, CEM, HUT and U93T whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab125218 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. The detection limit for ab125218 is 1ng/lane under non-reducing and reducing conditions.
IHC-P Use a concentration of 1 µg/ml.

Target

  • FunctionRequired for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
  • Sequence similaritiesContains 1 GST C-terminal domain.
  • Post-translational
    modifications
    Phosphorylated on serine residues in response to UV irradiation.
    Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
  • Cellular localizationCytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aimp2 antibody
    • AIMP2_HUMAN antibody
    • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
    • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
    • ARS interacting multi functional protein 2 antibody
    • JTV 1 antibody
    • JTV 1 protein antibody
    • JTV1 antibody
    • JTV1 gene antibody
    • Multisynthase complex auxiliary component p38 antibody
    • Multisynthetase complex auxiliary component p38 antibody
    • P38 antibody
    • PRO0992 antibody
    • Protein JTV 1 antibody
    • Protein JTV-1 antibody
    • tRNA SYNTHETASE COFACTOR p38 antibody
    see all

Anti-AIMP2/p38 antibody images

  • All lanes : Anti-AIMP2/p38 antibody (ab125218) at 1 µg/ml

    Lane 1 : Rat liver tissue lysate
    Lane 2 : Rat lung tissue lysate
    Lane 3 : Rat kidney tissue lysate
    Lane 4 : Rat brain tissue lysate
    Lane 5 : Rabbit IgG (55kDa)
    Lane 6 : Jurkat whole cell lysate
    Lane 7 : CEM whole cell lysate
    Lane 8 : HUT whole cell lysate
    Lane 9 : U93T whole cell lysate


    Predicted band size : 35 kDa
  • ab125218 at 1ug/ml in paraffin embedded Human tumour tissue by immunohistochemistry.

References for Anti-AIMP2/p38 antibody (ab125218)

ab125218 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"