Overview

  • Product name
  • Description
    Mouse polyclonal to AIMP2/p38
  • Specificity
    This antibody is reactive against mammalian transfected lysate.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length AIMP2/p38 protein (Human)

  • Positive control
    • AIMP2/p38 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500 - 1/1000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
    • Sequence similarities
      Contains 1 GST C-terminal domain.
    • Post-translational
      modifications
      Phosphorylated on serine residues in response to UV irradiation.
      Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
    • Cellular localization
      Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Aimp2 antibody
      • AIMP2_HUMAN antibody
      • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody
      • Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody
      • ARS interacting multi functional protein 2 antibody
      • JTV 1 antibody
      • JTV 1 protein antibody
      • JTV1 antibody
      • JTV1 gene antibody
      • Multisynthase complex auxiliary component p38 antibody
      • Multisynthetase complex auxiliary component p38 antibody
      • P38 antibody
      • PRO0992 antibody
      • Protein JTV 1 antibody
      • Protein JTV-1 antibody
      • tRNA SYNTHETASE COFACTOR p38 antibody
      see all

    Images

    • All lanes : Anti-AIMP2/p38 antibody (ab67471) at 1/500 dilution

      Lane 1 : AIMP2/p38 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 35 kDa
      Observed band size : 35 kDa

    References

    ab67471 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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