Application notesELISA:Peptide ELISA: antibody detection limit dilution >1/32000.
Western Blot: No signal obtained yet but a preliminary experiment showed low background in Human Brain extract at up to 1µg/ml.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionSeems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.
Tissue specificitySpecifically expressed in brain.
Sequence similaritiesBelongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 6 PDZ (DHR) domains. Contains 2 WW domains.