• Product nameAnti-AK2 antibody
    See all AK2 primary antibodies
  • Description
    Rabbit polyclonal to AK2
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the C terminal region of human AK2.

  • Positive control
    • Jurkat cell lysate and human cancer tissue (hepatocarcinoma)


Associated products


Our Abpromise guarantee covers the use of ab71729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
WB 1/1000. Detects a band of approximately 26 kDa (predicted molecular weight: 26 kDa).


  • FunctionCatalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.
  • Tissue specificityPresent in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
  • Involvement in diseaseDefects in AK2 are the cause of reticular dysgenesis (RDYS) [MIM:267500]; also known as aleukocytosis. RDYS is the most severe form of inborn severe combined immunodeficiencies (SCID) and is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune functions, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal.In addition, affected newborns have bilateral sensorineural deafness. Defects may be due to its absence in leukocytes and inner ear, in which its absence can not be compensated by AK1.
  • Sequence similaritiesBelongs to the adenylate kinase family. AK2 subfamily.
  • Cellular localizationMitochondrion intermembrane space.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenylate kinase 2 antibody
    • adenylate kinase 2, mitochondrial antibody
    • Adenylate kinase isoenzyme 2 antibody
    • ADK2 antibody
    • AK 2 antibody
    • ak2 antibody
    • ATP AMP transphosphorylase antibody
    • ATP-AMP transphosphorylase 2 antibody
    • EC antibody
    • KAD2_HUMAN antibody
    • mitochondrial antibody
    see all

Anti-AK2 antibody images

  • Anti-AK2 antibody (ab71729) at 1/100 dilution + Jurkat cell lysate at 12.5 µg

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
    Additional bands at : 15 kDa,62 kDa. We are unsure as to the identity of these extra bands.
  • ab71729, at a 1/50 dilution, staining AK2 in formalin fixed, paraffin embedded human cancer tissue (hepatocarcinoma) by Immunohistochemistry. ab71729 was peroxidase conjugated to the secondary antibody, followed by AEC staining.

References for Anti-AK2 antibody (ab71729)

ab71729 has not yet been referenced specifically in any publications.

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