The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 36 kDa.
Use a concentration of 5 µg/ml.
Use a concentration of 10 µg/ml.
FunctionActs as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Tissue specificityFound in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Sequence similaritiesBelongs to the aldo/keto reductase family.
Cellular localizationLysosome. Secreted. Secreted through a lysosome-mediated non-classical pathway.
ab109998, at 10 µg/ml, staining AKR1B10 in HeLa cells by immunoflourescence.
References for Anti-AKR1B10 antibody [1A6] (ab109998)
This product has been referenced in:
Agyeman AS et al. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Res Treat132:175-87 (2012).
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