FunctionEfficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Tissue specificityHighly expressed in liver. Expressed in testis and weakly in colon.
Involvement in diseaseCongenital bile acid synthesis defect 2
Sequence similaritiesBelongs to the aldo/keto reductase family.