Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.
Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.
Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using ab59667 at a dilution of 4-8 µg/ml, positively labelling epithelial cells of the renal tubule (indicated with arrows). Magnification 400X