Anti-ALDH4A1 antibody - C-terminal (ab80180)

Overview

  • Product nameAnti-ALDH4A1 antibody - C-terminal
    See all ALDH4A1 primary antibodies
  • Description
    Rabbit polyclonal to ALDH4A1 - C-terminal
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the C terminal region of human ALDH4A1.

  • Positive control
    • HepG2 cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab80180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 62 kDa (predicted molecular weight: 62 kDa).
ELISA 1/1000.

Target

  • FunctionIrreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
  • Tissue specificityHighest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
  • PathwayAmino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.
  • Involvement in diseaseDefects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2) [MIM:239510]. HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.
  • Sequence similaritiesBelongs to the aldehyde dehydrogenase family.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • AL4A1_HUMAN antibody
    • aldehyde dehydrogenase 4 antibody
    • aldehyde dehydrogenase 4 family, member A1 antibody
    • Aldehyde dehydrogenase family 4 member A1 antibody
    • Aldehyde dehydrogenase, family 4, subfamily A, member 1 antibody
    • ALDH4 antibody
    • aldh4a1 antibody
    • Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial antibody
    • Delta-1-pyrroline-5-carboxylate dehydrogenase antibody
    • L-glutamate gamma-semialdehyde dehydrogenase antibody
    • mitochondrial antibody
    • mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody
    • P5C dehydrogenase antibody
    • P5CD antibody
    • P5CDh antibody
    • P5CDhL antibody
    • P5CDhS antibody
    • Pyrroline-5-carboxylate dehydrogenase antibody
    • RP11 128M10.1 antibody
    see all

Anti-ALDH4A1 antibody - C-terminal images

  • Anti-ALDH4A1 antibody - C-terminal (ab80180) at 1/50 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size : 62 kDa
    Observed band size : 62 kDa
    Additional bands at : 30 kDa,36 kDa,90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-ALDH4A1 antibody - C-terminal (ab80180)

ab80180 has not yet been referenced specifically in any publications.

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