Overview

  • Product name
  • Description
    Goat polyclonal to ALDH5A1
  • Specificity
    ab106819 is expected to recognize both reported isoforms (NP_733936.1; NP_001071.1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog, Orangutan
  • Immunogen

    Synthetic peptide:

    C-TGKILLHHAANS

    , corresponding to internal sequence amino acids 288-299 of Human ALDH5A1 (NP_733936.1; NP_001071.1).

  • Positive control
    • Human, Mouse and Rat Liver lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab106819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 57 kDa.

Target

  • Function
    Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • Tissue specificity
    Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • Pathway
    Amino-acid degradation; 4-aminobutanoate degradation.
  • Involvement in disease
    Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • Sequence similarities
    Belongs to the aldehyde dehydrogenase family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aldedehyde dehydrogenase 5 family antibody
    • Aldehyde dehydrogenase 5 family member A1 antibody
    • Aldehyde dehydrogenase 5A1 antibody
    • Aldehyde dehydrogenase family 5 member A1 antibody
    • ALDH5A 1 antibody
    • Aldh5a1 antibody
    • mitochondrial antibody
    • Mitochondrial succinate semialdehyde dehydrogenase antibody
    • NAD(+) dependent succinic semialdehyde dehydrogenase antibody
    • NAD(+)-dependent succinic semialdehyde dehydrogenase antibody
    • SSADH antibody
    • SSDH antibody
    • SSDH_HUMAN antibody
    • Succinate semialdehyde dehydrogenase antibody
    • Succinate-semialdehyde dehydrogenase antibody
    see all

Images

  • Anti-ALDH5A1 antibody (ab106819) at 1 µg/ml (for 1 hour) + Human Liver lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 57 kDa

References

ab106819 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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